The changes in serum concentrations of the interferon-?-inducible protein 10(IP-10) in different types of diabetic patients and their significance
- VernacularTitle:不同类型糖尿病患者的血清干扰素?诱导蛋白10的改变及其意义
- Author:
Xia LI
;
Zhiguang ZHOU
;
Xiang YAN
- Publication Type:Journal Article
- Keywords:
Interferon-?-inducible protein 10;
Diabetes,type 1;
Diabetes,type 2
- From:Chinese Journal of Diabetes
2008;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of serum IP-10 levels in different types of diabetic patients. Methods Serum IP-10 level in 78 cases with type 1 diabetes,49 cases with type 2 diabetes and 33 cases of healthy controls was measured with ELISA assays. Type 1 diabetic patients were divided into classic type 1 diabetes (n=39) and latent autoimmune diabetes in adults (LADA,n=39) according to their disease process,and they were also divided into autoimmune type 1 diabetes (n=58) and idiopathic type 1 diabetes (n=20).Type 2 diabetic patients,according to carotid intima-media thickness (IMT),were divided into patients with (n=24) or without atherosclerosis (n=25). Results 1) Serum IP-10 levels were not statistically different among type 1 diabetes,type 2 diabetes and healthy controls. 2) Serum IP-10 concentrations in autoimmune type 1 diabetes with positive islet autoantibody were higher than those in healthy controls(184.96?104.48pg/ml vs 146.10?74.61pg/ml,P=0.03);while there were no difference in type 1 diabetes with variable disease durations. 3) No difference in IP-10 levels was found between type 2 patients with(173.5?69.6pg/ml) and without atherosclerosis (188.5?79.7 pg/ml). Conclusions Serum IP-10 level is augmented in autoimmune type 1 diabetes.
