Relationship of serum uric acid level with the different states of glucose metabolism and creatinine clearance rate
- VernacularTitle:血清尿酸水平与糖代谢状况及肌酐清除率的关系
- Author:
Lili HUO
;
Linong JI
- Publication Type:Journal Article
- Keywords:
Serum uric acid;
Creatinine clearance rate;
Hyperuricemia;
Impaired glucose regulation;
Diabetes mellitus
- From:
Chinese Journal of Diabetes
2008;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of serum uric acid level with the different states of glucose metabolism and glomerular filtration rate (GFR) reflected by creatinine clearance rate and to test the hypothesis that increased GFR is one of the determinants of serum uric acid level. Methods 822 subjects with high risk factors for diabetes in Beijing area underwent a 75g oral glucose tolerance test (OGTT) for screening of diabetes. The subjects were divided into three groups:NGT,IGR and DM after OGTT. SUA and Ccr were compared between three groups. The general linear model was employed to test the relationships of the small FPG intervals with SUA and Ccr. Results The correlations of uric acid level with sex,BMI,TG,HbA1c and Ccr remained significant in a multiple regression analysis. After adjusting sex,BMI and TG,the newly diagnosed DM group had the lowest SUA level(P
