Significance of islet auto-antibodies and ?-cell function in patients with ketosis-prone diabetes
- VernacularTitle:酮症倾向的糖尿病患者胰岛自身抗体与胰岛功能的意义
- Author:
Mingjing BAO
;
Xuejun ZHANG
;
Pengqiu LI
- Publication Type:Journal Article
- Keywords:
Diabetes,ketosis-prone;
?-cell function;
Islet auto-antibodies
- From:Chinese Journal of Diabetes
2008;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of islet auto-antibodies and ?-cell function in patients with ketosis-prone diabetes(KPD). Methods A total of 78 patients with KPD were divided into four categorical groups based on the presence or absence of auto-antibodies (A+ or A-) and of ?-cell functional reserve(?+ ?-):A+?+(group 1,n=13),A-?-(group 2,n=18),A-?+(group 3,n=28),A+?-(group 4,n=19).Islet auto-antibodies,including glutamic acid decarboxylase antibody(GAD-Ab),islet cell antibody(ICA)and insulin autoantibody(IAA) were measured. The clinical characteristics,biochemical parameters and serum peptide were compared among four groups. Results Compared with group 1,2 and 4,group 3 showed the oldest age at onset,and higher levels of BMI,hypertension,serum triglyceride,cholesterol,fasting and postprandial C-peptide. Patients in group 2 had the youngest age at onset,the lowest level of serum C peptide. The phenotypes of patients in group 1 and group 4 were intermediate between group 2 and group 3. Conclusions About 39.7% of patients with KPD have positive islet auto-antibodies. Patients with KPD show significantly different levels of ?-cell function,clinical characteristics and biochemical parameters,which may need different therapeutic strategies.
