An experimental study on the treatment of steroid-induced femoral head necrosis with marrow mesenchymal stem cell transplantation
- VernacularTitle:骨髓间充质干细胞治疗早期股骨头坏死的实验研究
- Author:
Jianping YANG
;
Liming WANG
;
Yan XU
;
Jinsong WANG
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cell;
Treatment;
Early femoral head necrosis;
Experimental study
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of marrow mesenchymal stem cell(MSC) transplantation on earlier femoral head necrosis and its action mechanism.Methods: After establishment of steroid-induced femoral head necrosis models in 60 New Zealand white rabbits,we selected 36 of them with diagnosed femoral head necrosis and randomly divided them into Group A(untreated control),B(decompression only) and C(decompression + MSC transplantation).Four and 8 weeks after the operation,6 rabbits were taken from each group for MRI scanning,and then killed and their bilateral femoral heads harvested for H-E and CD34 immunohistological staining and scanning electron microscopy(SEM).Results: Eight weeks after the treatment,MRI showed an obvious minification of the low signal region,and histopathology and SEM revealed a decrease of empty lacunae,an increase of osteoblasts and new bone formation in group C,with significant differences from the other two groups in the positive rate of empty lacunae and the density of microvessels(P
