The Reciprocal Modulation Between Epigenetic and microRNA and The Application for Treatment of Malignant Tumors
- VernacularTitle:表观遗传与microRNA相互调控机制以及在抗肿瘤领域内的应用
- Author:
Yanmin XU
;
Yanhe GUO
;
Li LIU
;
Rong CAI
;
Cheng QIAN
- Publication Type:Journal Article
- Keywords:
miRNA, epigenetics, oncogenesis
- From:
Progress in Biochemistry and Biophysics
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
The recent investigations have demonstrated that epigenetic such as DNA methylation and histone modification was closely associated with cell growth and malignant tumors, and epigenetic modification was responsible for an important cause of oncogenesis. However, for the recent years some observations have been also shown that the development of tumorigenesis was attributed to transformation expression in microRNA. The latest investigations have revealed that epigenetic was involved in modulation of microRNA expression, on the contrary some kinds of microRNAs could also control epigenetic, moreover, the reciprocal modulation between microRNA and epigenetic could regulate gene expression and induce tumorigenesis. At the same time the data likewise displayed that epigenetic adjusted microRNA expression principally in a way of DNA methylation or histone modification, nevertheless microRNA regulated epigenetic by way of methyltransferases expression, DNA methylation maintenance and histone modification. With regard to the reciprocal modulation between microRNA and epigenetic, a comprehensive and systemic review of reciprocal relationship in modulation of cell growth and oncogenesis was gived.
