Expression of TIMP-1 in brain tissue of perihematoma and relationship between TIMP-1 and brain edema in experimental intracerebral hemorrhage
- VernacularTitle:实验性脑出血血肿周围脑组织基质金属蛋白酶组织抑制剂-1的表达及其与脑水肿的关系
- Author:
Hui ZHAO
;
Chuanling LI
;
Qingguang WANG
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
brain edema;
TIMP-1
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of TIMP-1 in brain tissue of perihematoma and the relationship between TIMP-1 and brain edema in experimental intracerebral hemorrhage(ICH). Methods ICH models of rats were established by autologous blood injection. Then the brain water content was measured by comparion of wet and dry weight,the permeability of blood-brain barrier (BBB) was evaluated by evans blue contents,and the expression of TIMP-1 in brain tissue of perihematoma was detected by Western Blot at 1 h,3 h,6 h,12 h,24 h,36 h,48 h,72 h and 7 d total 9 time points after ICH. The relationship among the results were analysed,and compared with the sham operation group. Results Compared with the sham operation group,the brain water contents and evans blue contents were significantly increased at all the time points in ICH group (P
