Clinical study of Tanshinone ⅡA for treatment on acute cerebral infarction
- VernacularTitle:丹参酮ⅡA治疗急性脑梗死的临床研究
- Author:
Xuan ZHANG
;
Linting ZHANG
- Publication Type:Journal Article
- Keywords:
TanshinoneⅡA;
acute cerebral infarction
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and mechanism of Tanshinone ⅡA for treatment on acute cerebral infarction(ACI). Methods 104 patients with ACI were randomly divided into Tanshinone group (50 cases) and control group (54 cases),and were treated with conventional therapy. While,Tanshinone ⅡA was added by intravenous drop in Tanshinone group for 2 weeks. Neurological functional deficit scores,Barthel index(BI) were observed,the levels of serum superoxide dismutas(SOD),lipid peroxide (LPO) and malondialdehyde (MDA) were detected pre and post treatment. The efficacy was compared in the two groups.Results After 2 weeks of treatment,the score of National institute of health stroke scale (NIHSS) was decreased,BI was increased,the level of serum SOD was increased,the levels of serum LPO and MDA were decreased in the two groups. Compared with those in pre treatment,the changes of all the targets were significantly different (all P
