Progress of in vivo use of RNA interference
- VernacularTitle:RNA干扰的体内应用研究进展
- Author:
Junyan AN
;
Xiaolan ZHANG
- Publication Type:Journal Article
- Keywords:
RNA interference;
siRNA;
gene silencing;
gene therapy
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
RNA interference(RNAi),the first method of choice to suppress gene expression in vitro,is a conserved biologic response to double-stranded RNA that resulted in the sequence-specific silencing of target gene expression.Recently,more than 100 literatures reported synthetic small interfering RNAs in mammals.These reports demonstrated that RNAi is also a powerful tool for in vivo research and may become an effective therapeutic tool.This paper reviews the influencing factors and experimental design of in vivo use of RNAi.
