Neuroprotective effects of phycocyanin by internal carotid artery injection in acute cerebral infarction in rats
- VernacularTitle:颈内动脉注射藻蓝蛋白对大鼠急性脑缺血再灌注损伤的保护作用
- Author:
Rui ZHANG
;
Wenzhen LU
;
Hongyun LI
;
Yunlian GUO
- Publication Type:Journal Article
- Keywords:
phycocyanin;
acute cerebral ischemia;
brain edema;
apoptosis
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the neuroprotective effects of phycocyanin injection by internal carotid artery in acute cerebral ischemic reperfusion in rats.Methods The model of middle cerebral artery occlusion reperfusion(MCAO/R) was established using the intraluminal filament occlusion with 84 healthy adult male Wistar rats,and treated by phycocyanin injection through internal carotid artery.The nervous function scores,brain water content,cerebral infarction volume and cell apoptosis in brain tissues and the phycocyanin effects on above indexes were measured respectively.Results The rats showed some extent of neurobehavioral function disorders after ischemic reperfusion.In phycocyanin group rats,the nervous function scores,brain water content,cerebral infarction volume and the number of apoptotic cells in cortex,striatum and hippocampus reduced significantly compared to the model group.Conclusion phycocyanin injection through internal carotid artery showed obvious neuroproctective effects in acute cerebral infarction in rats.
