Enalapril increases synaptophysin expression in the hippocampus of streptozotocin-induced diabetic rats
- VernacularTitle:依那普利增加糖尿病大鼠海马组织内突触素的表达
- Author:
Yuan GAO
;
Qian XIAO
- Publication Type:Journal Article
- Keywords:
enalapril;
Diabetes;
cognition;
synaptophysin
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of enalapril on spatial learning and memory,and to identify synaptophysin expression in hippocampus of streptozotocin-diabetic rats.Methods Forty rats were randomly divided into control group,diabetic model group and the enalapril treatment group.Streptozotocin-diabetic rat model was developed.The diabetic rats were treated with enalapril for 12 weeks.Then,the learning and memory abilities of rats were tested with Morris water maze;mRNA and protein expression of synaptophysin in hippocampus was detected by RT-PCR and immunostaining.Results Compared with diabetic model group,the enalapril treatment group showed a significant decrease in the mean time of escape latencies(P
