Review on Rapamycin as a potential therapeutic agent against neurodegenerative disease
- VernacularTitle:雷帕霉素抗神经退行性病研究进展
- Author:
Guang YANG
;
Yuangang ZHU
;
Hui YANG
- Publication Type:Journal Article
- Keywords:
autophagy;
rapamycin;
neurodegenerative disease;
therapeutic agent
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy contributes to the pathology of various neurodegenerative conditions.Rapamycin,an agent against Candida albicans or immunosuppressive,was found to be effective against tumor.Furthermore,it also induces autophagy by inactivating the protein mammalian target of rapamycin(mTOR),FKBP and VMP1,thus could offer a tractable therapeutic agent for neurodegenerative diseases.
