Change of GFAP and NSE protein expression in brain of Alzheimer's disease model rats
- VernacularTitle:拟老年痴呆大鼠脑中GFAP和NSE蛋白表达的改变
- Author:
Yingying ZHU
;
Daofeng NI
;
Caimin XU
- Publication Type:Journal Article
- Keywords:
model of Alzheimer's disease;
rats olfactory bulb;
hippocampi;
glial fibrillary acidic protein;
neuron-specific enolase
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the difference in expression of glial fibrillary acidic protein and neuron-specific enolase in hippocampi and olfactory bulb of Alzheimer's disease rats,and the relationship between olfactory and Alzheimer's disease.Methods Adult rats,the expression of GFAP and NSE in hippocampi and olfactory bulb was measured by immuhistochemical after a single intracerebroventricular injection of ?-amyloid peptide,and change of these protein in olfactory.Results Comparing the hippocampi and olfactory of model and control,the expression of GFAP in model group increased evidently,the expression of NSE descended animals.Conclusion There is significant difference in olfactory system between Alzheimer's disease model and control group rats.
