Expression of JAB1 and P27~(kip1) in liver tissue of patients with hepatocellular carcinoma and its clinical significance
- VernacularTitle:肝细胞癌患者肝组织中JAB1和P27~(kip1)的表达变化及其临床意义
- Author:
You WANG
;
Mudan LU
;
Peng LI
;
Xiaopeng CUI
;
Aiguo SHEN
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
prognosis;
JAB1;
P27
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of C-JUN activation domain binding protein 1(JAB1)and its relationship with expression of P27 protein in human hepatocellular carcinoma(HCC),and to determine whether JAB1 is associated with clinicopathological parameters and prognosis of HCC.Methods Immunohistochemical analysis was performed to investigate the expression of JAB1 and P27 in 76 cases of HCC and adjacent nontumorous tissues.Fresh tumor tissues and their adjacent nontumorous tissues from 8 cases of HCC were collected for Western blot and immunoprecipitation assays.Results The expression of JAB1 in HCC was significantly higher than that in adjacent nontumorous tissues.In contrast,P27 level was higher in nontumorous liver tissues than that in HCC.JAB1 overexpression was correlated with histological differentiation,serum alpha-fetoprotein(AFP)level and metastasis(P
