Overexpression of anchor attachment protein in colorectal carcinoma
- VernacularTitle:Anchor Attachment蛋白在结直肠癌中表达增强
- Author:
Fuyi ZUO
;
Shiyong LI
;
Bo YU
;
Ping AN
;
Mei YANG
- Publication Type:Journal Article
- Keywords:
colorectal neoplasm;
Anchor Attachment protein;
tumor infiltration;
metastasis
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of anchor attachment protein(AAP)in colorectal carcinoma tissues and serum level of AAP in colorectal carcinoma patients and to identify the relationship among AAP expression,lymph node and liver metastases.Methods Immunohistochemistry was used to detect AAP expression,and ELISA was used to test AAP level in peripheral vein blood in 83 patients with colorectal carcinoma.Results The expression rate in normal colorectal mucosa,primary cancer,lymph nodes and liver metastases were 20.5%、53.0%、69.8% and 80.0%,respectively.The positive rate of AAP in primary cancer,lymph nodes and in liver metastasesfoci was higher than that in normal mucosa(P
