Effect of GSTT on potassium current of ischemic cardiocytes in guinea pigs
- VernacularTitle:蒺藜皂苷对成年豚鼠心室肌细胞钾电流的影响
- Author:
Hong LI
;
Shuang ZHANG
;
Zhuo SHI
;
Shijie YANG
- Publication Type:Journal Article
- Keywords:
Gross Saponins of Tribulus Terrestris;
action potential duration;
potassium current
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Study the effect of Gross Saponins of Tribulus Terrestris on active potential and potassium current of ischemic cardiocytes in guinea pigs,and approach its initial anti-arrhythmia effect and mechanism.Methods The cardiocytes of adult guinea pigs were isolated and hypoxia models were set up,the effects of injected GSTT on the cellular membrane active potential and electricity flow of potassium channel were recorded with whole cell patchclamp system.Results Compared with model group,the active plateau period(50% and 90%) of myocytes in GSTT 30 mg?L-1 group prolonged(P
