Effect of HBV replication on levels of IL-12 and IL-18 in peripheral blood in patients with hepatitis B-related cirrhosis
- VernacularTitle:乙型肝炎肝硬化患者HBV复制对外周血IL-12和IL-18表达水平的影响
- Author:
Yongsheng CHEN
;
Dongfu LI
;
Xiaoyang LIU
;
Jian ZHOU
- Publication Type:Journal Article
- Keywords:
hepatitis B,chronic;
liver cirrhosis;
virus replication;
interleakin-12;
interleukin-18
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and clinical significance of HBV replication on the serum levels of IL-12 and IL-18 in patients with hepatitis B-related cirrhosis.Methods The levels of HBV-DNA and IL-12 and IL-18 in peripheral blood from 136 patients with different clinic types chronic hepatic diseases(102 patients with chronic hepatitis B,34 patients with hepatitis B-related cirrhosis ),95 HBV carriers and 20 healthy people (as control group) were respectively detected with ELISA and real time PCR.Results The levels of IL-12 and IL-18 in chronic hepatitis B and hepatitis B-related cirrhosis groups were significantly increased compared with control group(P0.05); and there was positive relationship between prevalence of HBV replication and IL-12,IL-18 levels in different chronic hepatic disease groups(r=0.74,P
