Expression of muc-1 gene in non-small cell lung cancer and its clinical significance
- VernacularTitle:muc-1基因在非小细胞肺癌组织中的表达及临床意义
- Author:
Guanghu LI
;
Wei LIU
;
Tong FU
;
Guojin LIU
- Publication Type:Journal Article
- Keywords:
carcinoma,non-small cell lung;
RT-polymerase chain reaction;
muc-1
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between expression of muc-1 gene in non-small cell lung cancer (NSCLC) tissues and lymph node metastasis and its clinical significance.Methods The expression of muc-1 gene in 36 specimens of NSCLC tissues and 10 normal lung tissues were determined by RT-PCR.Results muc-1 gene was positively expressed in 19 of 36 specimens of NSCLC tissues,the positive expression rate was 52.7%.The expression of muc-1 mRNA in NSCLC tissues was related to metastasis of lymph node(?2 =6.733,P0.05).The positive expression rate of muc-1 gene was higher in NSCLC tissues with lymph node metastasis(N0 10%,N1 58.82%,N2 88.9%).Conclusion The lymph node metastasis rate in NSCLC patients with muc-1 gene positive expression is higher,the detection of muc-1 gene expression can guide the prognosis and therapy of NSCLC patients after operation.
