Synergetic effects of stress and nicotine on periodontal tissues in rats
- VernacularTitle:应激和尼古丁对大鼠牙周组织的协同破坏作用
- Author:
Bo LI
;
Chongtao LIN
;
Yingli ZHANG
;
Chunhua ZHOU
- Publication Type:Journal Article
- Keywords:
stress;
nicotine;
periodontal tissue;
disease models,animal
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of stress associated with nicotine on experimental periodontal breakdown of ligature-induced periodontitis in rats.Methods Forty male Wistar rats with the neck of left maxillary second molar ligated by nylon were used.The animals were randomly divided into four groups:Ni group,0.7 mg of nicotine?kg-1?d-1 (intraperitoneal); S group,stress (immobilization-12 h?d-1); Ni+S group,stress (immobilization-12 h?d-1) associated with an intraperitoneal injection of 0.7 mg of nicotine?kg-1?d-1; C group:saline solution. Two rats of each group were sacrificed at the day of 2,4,6,8,10 separately and the furcation areas of the second maxillary molars were examined histologically and histometrically.Results Intergroup analysis revealed a higher bone loss rate in the animals of Ni+S group compared with the other three groups,the absorption rate of alveolar bone at the day of 6,8,10 in experimental groups were higher than that in C group (P
