Progress and application of atomic force microscope concerning mechanical properties of cells
- VernacularTitle:原子力显微镜在细胞力学性质方面的研究与应用
- Author:
Xiaofang CAI
;
Hua DENG
;
Jiye CAI
;
Xun HUANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(48):-
- CountryChina
- Language:Chinese
-
Abstract:
Atomic force microscope(AFM) has one important feature that it is used to scan the samples with non-modified and modified probes to obtain sample appearance,and force-distance curve at certain point,based on which the adhesion,bond force and mechanical properties of the sample can be obtained.Until recently,the application of the AFM to measure the mechanical properties of biological sample is very extensive,which is significant in biomedicine and clinical medicine.This paper introduced the force curve theory of AFM,and reviewed the application of AFM to measure the mechanical properties of biological sample including elasticity,adhesion,stiffness,the interaction between antibody and antigen of the cell.In addition,we prospected the application and development of AFM to analyze cell mechanical properties.
