Impact of spontaneously hypertensive diabetes mellitus on myocardial cell structure and cardiac function in rats
- VernacularTitle:高血压合并糖尿病大鼠心肌细胞结构及心功能的观察
- Author:
Yanyan WANG
;
Xunmin CHENG
;
Hangbo ZHOU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Diabetes mellitus;
Cardiac function
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the impact of spontaneously hypertensive diabetes mellitus(SHDM) on myocardial cell structure and cardiac function.Methods: Twenty-four SD rats were equally divided into an SD(control),a DM,an SH and an SHDM group.DM and SHDM were induced in the SD and SH rats by intraperitoneal injection of streptozotocin combined with high fat diet,followed by invasive detection of the cardiac function and pathological examination of the myocardial cell structure 16 weeks later.Results: Disorganized array,decreased interspaces,scattered degenerate necrosis and damaged mitochondria were observed in the cardiac cells of the SHDM group.The left ventricular end-diastolic pressure(LVEDP) was significantly higher in the SH,DM and SHDM groups than in the SD group(P
