Oxidative stress and oxidative stress-mediated cell apoptosis in diabetic nephropathy
- VernacularTitle:氧化应激及其介导的细胞凋亡在糖尿病肾病中的作用
- Author:
Limin SHEN
;
Chenguang WU
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
Reactive oxygen species;
Apoptosis;
Diabetic nephropathy
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Reactive oxygen species(ROS) resulting from oxidative stress plays a significant role in the pathogenesis of diabetic nephropathy.It induces cell apoptosis and accelerates the development and progression of diabetic nephropathy through mitochondrial activation,DNA oxidative injury and influence on gene expression.Reducing ROS formation and blocking the pathway of cell apoptosis activated by ROS may become a new target in the treatment of diabetic nephropathy.
