Regulation of Th1 and Th2 Type Cytokines in the NCC Patients Treated with Praziquantel
- VernacularTitle:吡喹酮治疗脑囊虫病患者血清中Th1/Th2细胞因子的变化及临床意义
- Author:
Yajie LI
;
Weizhe ZHANG
;
Xiaoli ZHANG
;
Suqin MA
- Publication Type:Journal Article
- Keywords:
neurocysticercosis (NCC);
praziquantel;
cytokine
- From:
Journal of Tropical Medicine
2004;4(3):227-229,233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore immunological mark and the outcome of disease after pharmacological treatment in human NCC with praziquantel. Methods 35 patients were treated with praziquantel for 6 months. Levels of serum IL-2,IFN-γ, IL-12, IL-5, IL-10 and TNF-α were measured before and after treatment. Results Th1 type cytokines IL-2, IFN-γand IL-12 were up regulated after treatment( P ＜ 0. 01 ) . Levels of TNF-α and Th2 type cytokines IL-5 and IL-10 were remarkable decreased after treatment( P ＜ 0. 01 ). The levels of IL-2, IFN-γ and IL-12 from the patients with good response to the treatment is higher than those with no response to the treatment. Conclusion Th1 type cytokines were up regulated while Th2 type cytokines were down regulated in the NCC patients treated with praziquantel. The protective immunity may be related to the Thl cell activation.
