Antimicrobial Activity of Recombinant Human ?-Defensin 3 on Clinically Isolated Multidrug-resistant Strains
- VernacularTitle:重组人?-防御素3对临床分离多药耐药菌的抗菌活性分析
- Author:
Xiaoye TUO
;
Jiake CHAI
;
Wei JIANG
;
Dong CHANG
;
Zhiyong SHENG
- Publication Type:Journal Article
- Keywords:
?-Defensin 3;
Gene engineering;
Antimicrobial activity;
Turbidity method
- From:
Chinese Journal of Nosocomiology
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the antimicrobial activity of recombinant human ?-defensin 3(rhBD-3) on clinically isolated multidrug-resistant bacterial strains.METHODS The antimicrobial activity of rhBD-3 on clinically isolated multidrug-resistant Staphylococcus aureus,Enterococcus faecium,Acinetobacter baumannii and Pseudomonas aeruginosa from the wards of burns department was measured by turbidity method.RESULTS rhBD-3 Demonstrated antimicrobial activity against all the strains in a dose-dependent manner.The minimal inhibitory concentration(MIC) to Gram-positive strains and Gram-negative strains was 4 ?g/ml and 8 ?g/ml,respectively.CONCLUSIONS rhBD-3 Has significant antimicrobial activity against clinically isolated multidrug-resistant strains and thus implies therapeutic potential as an effective substitute for the present drug-resistant bacteria.
