Expression of platelet-derived growth factor-BB and its mRNA in patients with hepatic diseases
- VernacularTitle:肝病患者外周血血小板衍生生长因子-BB及其mRNA的表达
- Author:
Zhuying HUANG
;
Pingbang WANG
;
Xinmin NIE
;
Rong GUI
;
Mingsheng SONG
- Publication Type:Journal Article
- Keywords:
Platelet-derived growth factor-BB;
chronic hepatitis;
post-hepatitis cirrhosis;
primary hepatocellular carcinoma
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of platelet-derived growth factor-BB (PDGF-BB) and its role in the pathogenesis of the patients with hepatic diseases.Methods The levels of serum PDGF-BB in 30 chronic patients (hepatitis B,26; hepatitis C,4),24 patients with post-hepatitis cirrhosis,30 patients with primary hepatocellular carcinoma,and 20 normal controls were measured by ELISA.The levels of PDGF-B mRNA in peripheral blood mononuclear cells were measured by reverse transcription polymerase chain reaction (RT-PCR).Results The serum levels of PDGF-BB and the levels of PDGF-B mRNA in peripheral blood mononuclear cells were significantly higher in the patients with hepatic diseases (F=1774.40,1037.42,P
