Reviews on The Immunological Function of Tetraspanins
- VernacularTitle:四跨膜蛋白超家族tetraspanins的免疫功能研究进展
- Author:
Lang GUI
;
Bing WANG
;
Fuhua LI
;
Jianhai XIANG
- Publication Type:Journal Article
- Keywords:
tetraspanins, immunity, virus, transmembrane 4 superfamily, invertebrate
- From:
Progress in Biochemistry and Biophysics
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Tetraspanins belongs to the transmembrane 4 superfamily(TM4SF). They can be as a bridge to connect the proteins outside or inside the cell membrane. A tetraspanins web is formed by the tetraspnins-proteins complex, and the web is believed to involve in fundamental functions of immunity system, and consequnently, signaling between cells and inside cells, regulating cell activation and adhesion, participating in the identification and infection of some virus. As a family of conservative transmembrane proteins, tetraspanins play multiplex roles in invertebrate. It was described how tetraspanin microdomains might have functions in the immune system, and how they contact with virus. In addition, the important role of tetraspanins in the innate immune system of invertebrate were discussed.
