Research progresses on pyruvate dehydrogenase kinases
- VernacularTitle:丙酮酸脱氢酶激酶的研究进展
- Author:
Jiyong JIAN
;
Yong ZHANG
;
Dahai ZHU
- Publication Type:Journal Article
- Keywords:
pyruvate dehydrogenase complex;
pyruvate dehydrogenase kinases;
diabetes;
heart ischemia;
cancer
- From:
Basic & Clinical Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Pyruvate dehydrogenase kinases(PDKs 1-4) can regulate the activity of mitochondrial pyruvate dehydrogenase complex(PDC) to catalyse the oxidative decarboxylation of pyruvate,and then to link glycolysis to the tricarboxylic acid cycle and ATP production.In this review,we summarize up-to-date information of mechanisms regulating PDKs and the function of PDKs inhibitors in lowering blood glucose level,alleviate damage during heart ischemia and also triggering apoptosis in cancer cells.PDKs will be a possible pharmacological targets in diabetes,heart ischemia and cancer therapy.
