Effect of transplanted human bone marrow mesenchymal stem cells on behavioral changes of cerebral ischemic rats
- VernacularTitle:人源性骨髓间充质干细胞移植对脑缺血大鼠的行为影响
- Author:
Junji WEI
;
Lifen ZENG
;
Renzhi WANG
;
Chunhua ZHAO
;
Ming FENG
;
Yu WANG
;
Guilin LI
;
Wanchen DOU
;
Yanguo KONG
- Publication Type:Journal Article
- Keywords:
bone marrow mesenchymal stem cells(BMSCs);
stem cell transplantation;
middle cerebral artery occlusion(MCAO);
behavioral research
- From:
Basic & Clinical Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate the behaviors of cerebral ischemic rats after treatment with bone marrow mesenchymal stem cells(BMSCs).Methods Bone marrow was collected and BMSCs were separated and cultivated.Twenty-four adult male Sprague-Dawley rats were performed transient(2 hours) middle cerebral arterial occlusion(MCAO) and then divided into treated group(n=12) and control group(n=12).All rats received corresponding behavioral training before surgery,15 ?L hBMSCs(2?1010cells/L) and D-hanks(15 ?L) were injected into the brain cortex after 24 h of MCAO.Morris water maze test,NSS,Rotarod test and adhesive-removal test were performed serially and cyclically from the 4th day after transplantation.Results Since the 8th day after transplantation,the mean escape time and the mean swimming distance of treated group significantly are shorter than control's in Morris water maze test(P
