Factors for restenosis following stent-assisted angioplasty of intracranial and extracranial arteries
- VernacularTitle:颅内外动脉狭窄支架置入后的再狭窄因素分析
- Author:
Yong CHEN
;
Lin GAO
;
Na CHANG
;
Weiya HE
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(44):-
- CountryChina
- Language:Chinese
-
Abstract:
Stent-assisted angioplasty of intracranial and extracranial arteries is a complex pathophysiologic process.Therefore,understanding of related factors is significant for guiding clinical treatment and reducing restenosis rate.Intravascular stent as a foreign body leads to platelet activation and aggregation,cytokine secretion,resulting in thrombosis and leukocyte aggregation at vessel injury site to produce cytokine and inflammatory reaction.In addition,the smooth muscle cells migrate to injury site and proliferate,leading to intimal hyperplasia,vessel wall reconstruction and intra-stent restenosis.Moreover,the restenosis following stenting is related to stent type and medicine supportive treatment.Drug-eluted stent with anti-inflammation and vascular smooth muscle cell proliferation can reduce body inflammation intensity and duration,and postoperative medicine supportive treatment can reduce incidence of intravascular restenosis.
