Association of fibrinogen ?G-455A polymorphism with plasma fibrinogen level in patients with coronary heart disease
- VernacularTitle:纤维蛋白原?G-455A基因多态性与血浆纤维蛋白原及冠心病的关系
- Author:
Huili MA
;
Ming LIU
;
Aijun SUN
- Publication Type:Journal Article
- Keywords:
Alleles;
Fibrinogen;
Coronary disease;
Angina pectoris
- From:
Chinese Journal of Interventional Cardiology
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate whether ?G-455A gene polymorphism increases the risk of coronary heart disease(CHD) due to elevated plasma fibrinogen.Methods A total of 1 485 patients who had received coronary angiography due to chest pain or suspected cardiac ischemia by non-invasive examination were included in the study.According to the angiographic results,all the patients were divided into the control group(n=466) and coronary heart disease group(n=1 019).Patients in the coronary heart disease group were further divided into stable angina pectoris group(SAP,n=674) and acute coronary syndrome group(ACS,n=345) according to their clinical presentation.We investigated G-455A polymorphism of ? fibrinogen gene and plasma fibrinogen level in all the patients.Results Increased plasma fibrinogen levels were observed in CHD groups compared with controls(ACS: 380.92?92.35 mg/dL,SAP: 352.49?94.89 mg/dL,control: 311.72?87.09 mg/dL,P
