Efficacy of Glycopyrrolate in Primary Hyperhidrosis Patients.
- Author:
Hyun Ho LEE
1
;
Do Won KIM
;
Do Wan KIM
;
Chan KIM
Author Information
- Publication Type:Original Article
- Keywords: anticholinergic agents; glycopyrrolate; primary hyperhidrosis
- MeSH: Anxiety; Anxiety Disorders; Autonomic Nervous System; Cholinergic Antagonists; Depression; Glycopyrrolate; Humans; Hyperhidrosis; Quality of Life; Sweat; Sweating
- From:The Korean Journal of Pain 2012;25(1):28-32
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Primary hyperhidrosis is a disorder of excessive sweating, which shares several features with anxiety disorders and has a negative impact on a patient's quality of life. Oral glycopyrrolate is one of the treatments available. There are a few published studies on the use of glycopyrrolate given orally in the treatment of hyperhidrosis. METHODS: Thies is study was a review of case notes in a series of 36 patients with primary hyperhidrosis. We made a comparison between the Keller's scale score of a pre-glycopyrrolate medication group and the Keller's scale score f a post-glycopyrrolate medication group. The Milanez de Campos score, Short Form_36 (SF-36) score, Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the two groups. RESULTS: In the post-glycopyrrolate medication group, there were declines in Keller's scale, and Milanez de Campos scale score and BAI score (P < 0.001). In addition, there were increases in SF_36 score in the post-glycopyrrolate medication group (P = 0.03) However, no changes were seen in, BDI score and ANS score in the post-glycopyrrolate medication group (P < 0.001). CONCLUSIONS: Glycopyrrolate is an effective initial method of treating primary hyperhidrosis that, reduces anxiety and improve patients' quality of life.
