Effects of Ginkgo biloba extract on volume of cerebral infarction and expression of caspase-3 in ischemic-reperfusion rats
- VernacularTitle:银杏叶提取物对缺血再灌注大鼠脑梗死体积及半胱氨酸蛋白酶表达的影响
- Author:
Dongxue ZHAO
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
ischemic-reperfusion;
caspase-3;
Ginkgo biloba extract
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Ginkgo biloba extract(EGb) on the volume of cerebral infarction and expression of caspase-3 in ischemic-reperfusion rats.Methods Setting up the brain ischemic and reperfusion model in rats by Nagasawa way.Both groups rats treated with small dose of EGb and large dose of EGb were injected intraperitoneally with EGb 50 mg/kg and 100 mg/kg at 30 min before the trial and 1 h after cerebral ischemic respectively.The infarction volume and caspase-3 expression were detected by TTC staining and immunohisto-chemistry.Then the results were compared with ischemic-reperfusion group.Results In groups treated with small dose of EGb and large dose of EGb,infarction volumes [(83.4?2.9)mm3,(37.0?2.5)mm3] were smaller obviously than that in the ischemic-reperfusion group [(138.8?6.1)mm3](all P
