Induction and differentiation of bone marrow mesenchymal stem cells
- VernacularTitle:骨髓间充质干细胞诱导分化特征
- Author:
Zibing HU
;
Rong ZENG
;
Weitao GUO
;
Hao LIN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(43):-
- CountryChina
- Language:Chinese
-
Abstract:
Present research of bone marrow mesenchymal stem cells (BMSCs) mainly contains the studies of the characteristics of biology, the induced differentiation, the mechanism of regulation and so on. The research of the characteristics of biology and the osteogenic and adopocitic induction are comparatively mature, showing many biological characteristics such as adherence, plasticity, heterology, self-renewal, rapid clone formation and transplantation. Adherence combined with density gradient centrifugation method is widely used in the isolation and purification of BMSCs. As to neural induction, there are many uncertainties, such as morphous of typical neurons, specific labeling, excitability, synaptic connection with other neurons, synaptic potential, and whether the induction of fully functional neurons from BMSCs is possible. In addition, the research of the regulation mechanism is mostly uncertain, and there are still many safety problems.
