Relationship of peroxisome proliferator-activated receptors-? with lipid and glucose metabolism
- VernacularTitle:过氧化物酶体增殖物激活受体-?与脂代谢和糖代谢的关系
- Author:
Jing WANG
;
Dalong ZHU
- Publication Type:Journal Article
- Keywords:
Peroxisome proliferator-activated receptor-?;
Genetic polymorphism;
Blood lipids;
Insulin resistance;
Type 2 diabetes
- From:
Journal of Medical Postgraduates
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Synthetic agonists of peroxisome proliferator-activated receptors-?(PPAR?) have an important role in the preclinical models of metabolic diseases.In the recent years,it has been demonstrated that PPAR? agonists can normalize blood lipids and reduce insulin resistance and adiposity in rodents and primates.PPAR? activation in the skeletal muscle regulates the oxidative capacity of the mitochondrial apparatus,switches fuel preference from glucose to fatty acids and reduces triacylglycerol storage.PPAR? agonists also reduce insulin levels in serum,increase the sensitivity of insulin and improve glucose-tolerance.The genetic polymorphism in PPAR? has been shown to be associated with blood lipids,obesity and type 2 diabetes.
