The Prediction for Alternative and Constitutive Splice Sites in Human Genome
- VernacularTitle:人类基因组中可变和组成性剪接位点的预测
- Author:
Lirong ZHANG
;
Liaofu LUO
;
Yongqiang XING
;
Hongying JIN
- Publication Type:Journal Article
- Keywords:
alternative splice,constitutive splice,quadratic discriminant analysis
- From:
Progress in Biochemistry and Biophysics
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Based on the conservation of nucleotides at splice sites, the characteristics of base composition and base correlation in the adjacent segment sequences, the distance between alternative donor or acceptor splice sites and the content of GC and TC near splice sites, the donor and acceptor splice sites for alternative and constitutive introns are predicted by use of the method of diversity measure combined with quadratic discriminant analysis. For alternative splice sites the total prediction accuracies are 87.9% and 89.9% for donors and acceptors respectively (with the chosen threshold -2). For constitutive splice sites the total accuracy are 92.8% and 94.3% for donors and acceptors respectively (with the chosen threshold -1).
