In-vitro Activity of Cefoperazone-sulbactam Combined with Minocycline or Levofloxacin against Multidrug-resistant Acinetobacter baumannii
- VernacularTitle:头孢哌酮/舒巴坦与2种抗菌药物联用对多药耐药鲍氏不动杆菌药敏试验研究
- Author:
Yanping LUO
;
Dingxia SHEN
;
Jiyong YANG
;
Lu XIN
;
Yaping XU
;
Yang SONG
- Publication Type:Journal Article
- Keywords:
Cefoperazone-sulbactam;
Minocycline;
Levofloxacin;
Acinetobacter baumannii;
FIC
- From:
Chinese Journal of Nosocomiology
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the antibacterial effect of cefoperazone-sulbactam combined with minocycline or levofloxacin against 110 strains of multidrug-resistant Acinetobacter baumannii.METHODS Checkerboard method was designed for the minimal inhibitory concentration(MIC) testing of cefoperazone-sulbactam combined with minocycline or levofloxacin against 110 strains of multidrug-resistant A.baumannii by agar dilution method,fractional inhibitory concentration(FIC) index was calculated according to MIC value.RESULTS The MIC50 of cefoperazone-sulbactam was reduced significantly and the antimicrobial activities were reinforced remarkably when combined with minocycline or levofloxacin.The FIC results suggested that the main action be synergistic and additivie(53%,59% and 39%,37%),there was less autonomy(8%,4%) and no antagonism.CONCLUSIONS Combined with minocycline or levofloxacin respectively,cefoperazone-sulbactam expresses synergism and additivity against multidrug-resistant A.baumannii and there is no autonomy and antagonism.
