Correlation among unexplained oligospermatism,azoospermatism and micro-deletion in AZF gene
- VernacularTitle:不明原因无精症及少精症的AZF微缺失的分析
- Author:
Xianggai ZHANG
;
Haiyan HUANG
;
Bangrong ZHAO
;
Xiujuan DONG
;
Jie LIU
;
Junrong YU
;
Fengqin TAN
- Publication Type:Journal Article
- Keywords:
azoospermatism;
oligospermatism;
AZF gene;
PCR method;
micro-deletion in gene
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association among oligospermatism,azoospermatism in male sterility patients and micro-deletion in AZF gene of Y chromosome and to establish a integrate clinical diagnostic method for screening micro-deletion in AZF gene in Chinese.Methods PCR method was used to detect micro-deletion in AZF gene in 62 oligospermatism and azoospermatism patients and 20 normal male controls.Results 13.64%(6/44) of oligospermatism patients and 22.22%(4/18) of azoospermatism patients presented micro-deletion.However,micro-deletion was not found in 20 normal male controls.Furthermore,micro-deletion occur mostly in AZFc region.Conclusion Micro-deletion of AZF gene from Y chromosome is one of the major risks for oligospermatism and azoospermatism.
