Inhibitory effect of recombinant human endostatin combined with rAd/P53 on transplanted human breast cancer in nude mice
- VernacularTitle:重组人血管内皮抑素联合重组人P53腺病毒对裸鼠乳腺癌移植瘤的抑制
- Author:
Guangzhang ZHAO
;
Xiaodong QI
;
Zhikun CHANG
- Publication Type:Journal Article
- Keywords:
endostatin;
adenovirus;
P53;
breast neoplasms;
nude mice
- From:
Chinese Journal of Cancer Biotherapy
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the inhibitory effect of recombinant human endostatin(ES)combined with rAd/P53 on transplanted human breast cancer cell MCF-7 in nude mice.Methods:Animal breast cancer model was established by inoculating MCF-7 cells in nude mice.The animals were randomized into control group,ES group,rAd/P53 group,and ES+ rAd/P53 group.The tumor growth was observed in each group and immunohistochemical method was employed to examine the microvessel density(MVD) and the expression of vascular endothelial growth factor(VEGF).Results:Tumor growth was significantly inhibited in all the 3 treatment groups(P
