Combined examination of serum cross-linked N-telopeptides of type Ⅰ collagen and bone sialoprotein in detection of bone metastasis of breast cancer and lung cancer
- VernacularTitle:联合检测血清NTx和BSP对乳腺癌和肺癌骨转移的意义
- Author:
Wei WANG
;
Yajie WANG
;
Qiang FU
- Publication Type:Journal Article
- Keywords:
N-telopeptides of type I collagen;
bone sialoprotein;
lung neoplasms;
breast neoplasms;
bone metastasis;
diagnosis;
prognosis
- From:
Chinese Journal of Cancer Biotherapy
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical significance of examining serum pyridinoline cross-linked N-telopeptides of type I collagen(NTx) and serum bone sialoprotein(BSP) in diagnosing bone metastasis of lung cancer and breast cancer.Methods:A total of 105 patients treated in the Oncology Department of Changhai Hospital were included in this study.Patients were divided into 2 groups:bone metastasis(n=50) and non-bone metastasis groups(n=55).The levels of serum NTx and serum BSP were measured by ELISA.Results:The levels of serum NTx and serum BSP in patients with bone metastasis were significantly higher than in those without bone metastasis(P
