Human Papillomaviruses and Cervical Cancer Vaccines: To Decode 2008 Nobel Prize in Physiology or Medicine
- VernacularTitle:人乳头瘤病毒及宫颈癌疫苗的研究——解读2008年诺贝尔生理学或医学奖
- Author:
Xuemei XU
- Publication Type:Journal Article
- Keywords:
human papillomavirus, cervical cancer, vaccine
- From:
Progress in Biochemistry and Biophysics
2006;0(10):-
- CountryChina
- Language:Chinese
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Abstract:
Human papillomaviruses are small DNA viruses and over 118 types have been identified. They often infect host through mucosal surface or skin. Some of them (types 6 and 11) cause benign tumors such as condylomas whereas others (16, 18 etc) cause malignant tumors such as cervical cancers. Currently, there are two kinds of HPV preventive vaccine have been approved to market abroad. This article reviews progress in the field of human papillomaviruses (HPVs) biology, mechanism of carcinogenesis by persistent infection of high risk HPVs, and the development of prophylactic and therapeutic viral vaccines.
