Study on immunofunction and immunoregulation post newcastle disease vaccination of chickens infected with chicken anemia virus
- Author:
Zhonggui LIU
;
Shimin ZHENG
;
Yanbo XU
;
Zhiyong ZHOU
;
Liping YANG
;
Guangxing LI
;
mamat AHMAT
- Publication Type:Journal Article
- From:
Chinese Journal of Pathophysiology
2001;17(8):781-
- CountryChina
- Language:Chinese
-
Abstract:
Chickens were infected with chicken anemia virus (CAV) at one-day-old and vaccinated with La Sota vaccine 8 days later. Meanwhile, uninfected chickens were vaccinated as controls. At 7, 14 and 28 days post vaccination, the content of IgG,IgM,IgA and HI titer in serum, the number of T cells, IgG, IgM and IgA antibody producing cells in thymus, bursa and spleen, the proliferative response of T、B cells, the inductive activity of interleukin 2 (IL-2) and interferon (IFN) in thymus and spleen were tested. The results showed that the content of IgG, IgM, IgA and hemoagglutination inhibition (HI) titer in serum, the number of T cells, IgG, IgM and IgA antibody producing cells in thymus, bursa and spleen, the proliferative response of T cells and B cells as well as the inductive activity of IL-2 and IFN in thymus and spleen of infected-vaccinated chickens significantly decreased compared with the control. These results indicated that the immunofunction and immunoregulation were dropped post ND vaccination of CAV-infected chickens.
