Autogenous and xenogenous osteochondral grafting and bone defect repair
- VernacularTitle:自体及异体骨软骨移植与骨缺损修复
- Author:
Shendong WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(40):-
- CountryChina
- Language:Chinese
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Abstract:
Currently, materials to repair bone defects are various. Ideal material for bone transplantation should have properties of osteogenesis, bone induction, bone conductibility and biocompatibility. Autogenous or xenogenous osteochondral graft, cartilaginous membrane or periosteum graft and chondrocyte graft are commonly used grafts. Autogenous osteochondral graft exhibits advantages such as reliable graft and high survival rate of chondrocyte. However, due to donor area limitation, autogenous osteochondral grafting cannot meet requirements of repairing long-segmental bone defects. Thus, various materials are applied to repair articular cartilage defects. Cartilaginous membrane is frequently used, but its source and prolonged operation time limit its application. Xenogenous osteochondral material is relatively easily to obtain, and its size and appearance are not vigorously confined. Xenogenous osteochondral graft has bioactivity and can response to recipient. However, rejection reaction limits its application. Cryopreservation can retain osteogenetic activity and minimize immunogenicity but the bone biomechanical intensity is still significantly inferior to autogenous bone. To construct bioactive bone graft with enhanced chondrogenic capacity of bone graft by stimulation of various growth factors is the tendency of study on bone grafting materials.
