Expressions of MMP-3,MMP-9 and TIMP-1 in patients with acute myocardial infarction and their significances
- VernacularTitle:MMP-3、MMP-9及TIMP-1在急性心肌梗塞中的表达及其意义
- Author:
Hongfang SHA
;
Ling QIN
;
Yang LI
;
Jiaying ZHANG
- Publication Type:Journal Article
- Keywords:
acute myocardial infarction;
matrix metalloproteinase-3;
matrix metalloproteinase-9;
inhibitor of metalloproteinases-1
- From:
Journal of Jilin University(Medicine Edition)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the levels of matrix metalloproteinase-3(MMP-3),matrix metalloproteinase-9(MMP-9) and inhibitor of metalloproteinases-1(TIMP-1) in patients with acute myocardial infarction(AMI) and mechanism of plaque rupture of coronary atherosclerosis.Methods Sixty-seven patients with AMI were selected,average invasion time was 3 h～5 d.40 cases of non-coronary heart disease were included in control group.The expressions of serum MMP-3,MMP-9,TIMP-1 and the levels of serum cTnI,CK-MB were analyzed by enzyme-linked immunosorbent assay.Results The serum MMP-3,MMP-9 and TIMP-1 levels in AMI group were higher than those in control group,there was significant difference between two groups(P
