Biocompatibility of cerebral intravascular stent
- VernacularTitle:脑血管支架的生物相容性
- Author:
Xingsheng WANG
;
Wencui XUE
;
Jie SU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(39):-
- CountryChina
- Language:Chinese
-
Abstract:
As a foreign body, intravascular stent will induce platelet aggregation on the stent surface and activate platelet system and coagulation system, resulting in thrombosis. Smooth muscle cells migrate to injured site and proliferate, leading to intimal hyperplasia and vessel wall remodeling, which induces restenosis. Incidence of intravascular restenosis is determined by stent type, disease of the host, severity of stenosis before implantation and remnant stenosis length following stenting. Inhibition of intimal hyperplasia or improvement of intima formation and vessel wall remodeling can effectively prevent restenosis. Currently, there are many drugs to prevent restenosis, including antiplatelet drug, anti-inflammatory growth factor inhibitor and anti-cell proliferation drugs.
