The clinical significance of lowering the cut-point of impaired fasting glucose:in view of insulin sensitivity and islet ? cell function
- VernacularTitle:从胰岛素敏感性和胰岛?细胞功能看空腹血糖受损切点下调
- Author:
Lihong ZHANG
;
Lingling XU
;
Hongding XIANG
- Publication Type:Journal Article
- Keywords:
Impaired fasting glucose;
Insulin sensitivity;
Islet ?-cell function
- From:
Chinese Journal of Diabetes
2008;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the features of insulin sensitivity and ?-cell function in a Chinese population with normal fasting glucose.Methods 2,388 subjects aged≥20 years were divided into 5 groups based on the results of oral 75-g glucose tolerance test(OGTT):low-NFG,mid-NFG,high-NFG,IFG,T2DM.We compared insulin secretion and insulin sensitivity using several indexes derived from OGTT.Results There was a progressive decline in indexes of ?-cell function and insulin sensitivity when moving from NFG to type 2 diabetes.Compared with subjects with mid-NFG(FPG 4.9～5.6mmol/l),subjects with high-NFG(FPG5.6～6.1mmol/l)were more resistant to insulin,and had reduced insulin secretion,higher plasma triglyceride level and reduced HDL cholesterol concentrations(P
