Discovery of a tumor resistance mouse and investigation of its mechanism
- VernacularTitle:一种自发抗肿瘤小鼠模型的建立及其抗肿瘤机制的研究进展
- Author:
Wanqing ZHOU
;
Fangqiu LI
- Publication Type:Journal Article
- Keywords:
Spontaneous regression/complete resistance mouse;
S180 tumor cell;
Innate immunity
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
A colony of mice with a unique trait of host resistance to tumorigenesis induced by transplantable cells has been established and studied by Cui Zheng et al.These spontaneous regression/complete resistance(SR/CR) mice possess a trait of resistance to a broad spectrum of tumors and can be transferred to cancer-sensitive mice,with an age-dependent spontaneous regression mediated mainly by innate leukocytes.This article reviews the discovery of the SR/CR mouse model and related study of its anti-cancer mechanism.
