Progress in The Relation Between Inhibitors of Differentiation and Cancer
- VernacularTitle:分化抑制因子与肿瘤相关性研究进展
- Author:
Chuandong ZHU
;
Xiaojun LI
- Publication Type:Journal Article
- Keywords:
inhibitors of differentiation, cancer, targeted therapy
- From:
Progress in Biochemistry and Biophysics
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The ubiquitously expressed family of Id(inhibitor of differentiation) helix-loop-helix(HLH) proteins function as dominant negative regulators of basic HLH (bHLH) transcriptional regulators. In eukaryotic organisms, Id proteins have been implicated in development, cell differentiation, proliferation, angiogenesis, invasion and migration. Recent studies revealed that Id proteins are not only significantly correlated with cancer progression and prognosis, but also exploited as a tumor therapeutic target. The roles of Id proteins in tumorigenesis were reviewed and the opportunities of Id proteins in cancer targeted therapy were discussed.
