Abdominal Infection of Rabbit due to Drug-resistant Bacteria:Establishment of Animal Model
- VernacularTitle:耐药菌腹腔感染兔动物模型的建立
- Author:
Jun YANG
;
Shuwen ZHANG
;
Chenghong YIN
;
Baoen WANG
- Publication Type:Journal Article
- Keywords:
Drug-resistance bacteria infection;
Animal model;
Rabbit
- From:
Chinese Journal of Nosocomiology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish a simple and stable animal model with abdominal infection due to drug-resistant bacteria.METHODS Forty healthy rabbit were infected by Klebsiella pneumoniae ATCC700603,and divided into three test groups:A1(bacterial dose 8?109CFU/kg),A2(bacterial dose 16?109 CFU/kg) and A3(bacterial dose 24?109 CFU/kg).Normal control group B was established at the same time.Vital signs,white blood cell count(WBC),blood and abdominal irrigating solution cultures and strain identification were observed at 12,24,48,72 and 96h after infection.Patho-samples were obtained after being executed.RESULTS The body temperature,WBC,heart rate(HR) and respiratory rate(R) in group A3 were significantly higher than groups A1 and B,after rabbits having being infected 12-24 hours.And it continued for 96 hours(P
