Combined Activity of Polymyxin B with Meropenem Against 110 Strains of Multidrug-resistant Acinetobacter baumannii
- VernacularTitle:多黏菌素B与美罗培南对110株多药耐药鲍氏不动杆菌联合药敏研究
- Author:
Yanping LUO
;
Xueying WANG
;
Dingxia SHEN
;
Xuchun LIU
;
Jingrong CAO
;
Xing WEI
- Publication Type:Journal Article
- Keywords:
Polymyxin B;
Meropenem;
Acinetobacter baumannii;
Combined drug sensitivity;
FIC
- From:
Chinese Journal of Nosocomiology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the antibiotic effects of polymyxin B combined with meropenem against 110 strains of multidrug-resistant Acinetobacter baumannii.METHODS The protocol was designed by checkerboard method and the MICs of polymyxin B combined with meropenem against the 110 strains of A.baumannii were determined by broth dilution method,the FIC index was calculated according to MIC results.RESULTS The percentage of the FIC indexes less than 0.5,from 0.5 to 1,from 1 to 2 and more than 2 were 98%,2%,0% and 0%,respectively.CONCLUSIONS When polymyxin B combined with meropenem against 110 strains of A.baumannii the synergism and additivity are the main,there are no autonomy and antagonism.
