Clinical Evaluation of Extending Administration Time of Meropenem in Treatment of Bacterial Infections in Surgical Intensive Care Unit
- VernacularTitle:延长美罗培南输注时间治疗外科重症监护病房严重感染的临床研究
- Author:
Shuangling LI
;
Dongxin WANG
- Publication Type:Journal Article
- Keywords:
Meropenem;
Surgical intensive care unit;
Bacterial infections;
Treatment
- From:
Chinese Journal of Nosocomiology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the clinical efficacy and safety of extending the administration time of meropenem in the treatment of moderate and severe bacterial infections in surgical intensive care uint(SICU) patients.METHODS Fifty patients with moderate and severe bacterial infections admitted to SICU were randomized to two groups: meropenem 30 min infusion group(n=25) and meropenem 3 h infusion group(n=25),the clinical efficacy and side-effects were observed between two groups.RESULTS Twenty-five patients were enrolled in meropenem 30 min infusion group with an effective rate of 48%,bacterial clearance rate of 26.9%.On the other hand,twenty-five patients were enrolled in meropenem 3 h infusion group with an effective rate of 60%,bacterial clearance rate of 43.5%.There were no significant differences between two groups(P=0.375,P=0.224,separately).CONCLUSIONS There are no significant differences between two groups on effective rate and bacterial clearance rate.
