Association of LCT-13910 C/T Polymorphism and Colorectal Cancer.
- Author:
Genco GENÇDAL
1
;
Esin SALMAN
;
Omer ÖZÜTEMIZ
;
Ulus S AKARCA
Author Information
- Publication Type:Original Article
- Keywords: Adenocarcinoma; Colorectal neoplasms; LCT gene; Lactose intolerance
- MeSH: Adenocarcinoma; Alleles; Colonoscopy; Colorectal Neoplasms*; Endoscopy; Genotype; Humans; Lactase; Lactose; Lactose Intolerance; Polymerase Chain Reaction; Polyps; Risk Factors
- From:Annals of Coloproctology 2017;33(5):169-172
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The activity of epithelial lactase (LCT) is associated with a polymorphism 13910 bp upstream in the lactase encoding gene. Because the association between the LCT-13910 polymorphism and the risk for colorectal cancer is not clear, we investigated the role of the LCT-13910 polymorphism as a potential risk factor for colorectal cancer and colorectal polyps in the Turkish population. METHODS: One hundred sixty-six subjects (74 with polyps, 44 with colorectal cancer, 48 controls), who had undergone a total colonoscopy between January 2012 and November 2012 in our endoscopy unit were genotyped for the LCT-13910 polymorphism by using the polymerase chain reaction and minisequencing. RESULTS: The CC genotype in the lactose gene 13910 locus, which is accepted as the genetic indicator of lactase deficiency, was determined as 83.7%. The CC genotype rate was determined as 89.1% in patients who had a history of lactose intolerance and 81.5% in those without a history of lactose intolerance (P = 0.236). No difference was detected between the patients who had colorectal polyp(s) and/or cancer and the controls with regard to the LCT-13910 polymorphism. No differences were determined between groups when they were compared with regard to the C or the T allele. CONCLUSION: No differences were detected between the patients who had colorectal polyp(s) and/or cancer and those with normal colonoscopy findings with regard to lactase gene polymorphisms. No differences were determined between the groups when they were compared with regard to the C or the T allele.
